超抗原
生物
T细胞受体
抗原
主要组织相容性复合体
MHC限制
抗原呈递
抗原处理
MHC II级
细胞生物学
T细胞
分子生物学
MHC I级
免疫学
免疫系统
作者
Paolo Dellabona,Jean Peccoud,John W. Kappler,Philippa Marrack,Christophe Benoist,Diane Mathis
出处
期刊:Cell
[Elsevier]
日期:1990-09-01
卷期号:62 (6): 1115-1121
被引量:429
标识
DOI:10.1016/0092-8674(90)90388-u
摘要
Superantigens, including the staphylococcal enterotoxins and the minor lymphocyte stimulatory antigens, are highly potent immunostimulatory molecules, capable of activating virtually all T cells that express particular T cell receptor (TCR) variable regions. Superantigen stimulation of T lymphocytes depends on major histocompatibility complex (MHC) class II molecules, so there has been some debate as to whether superantigens interact with the antigen binding "groove" on class II complexes, just like conventional peptide antigens, or whether they bind elsewhere and serve as TCR coligands. We compared the presentation of peptide antigens and superantigens by a panel of mutant-presenting cell lines, each displaying an A kappa alpha chain with a single alanine replacement along the alpha helix proposed to form one face of the groove. The negligible effect of these 30 mutations on superantigen presentation, versus their drastic consequences for peptide presentation, prompts us to conclude that superantigens interact with MHC class II molecules outside the groove.
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