生物
核受体
细胞生物学
细胞因子
转录组
细胞分化
胎儿
祖细胞
免疫学
过氧化物酶体增殖物激活受体
胎盘
受体
转录因子
基因表达
病理
干细胞
基因
医学
怀孕
生物化学
遗传学
作者
Christoph Schneider,Samuel Philip Nobs,Michael Kurrer,Hubert Rehrauer,Christoph Thiele,Manfred Köpf
出处
期刊:Nature Immunology
[Springer Nature]
日期:2014-09-28
卷期号:15 (11): 1026-1037
被引量:428
摘要
Tissue-resident macrophages constitute heterogeneous populations with unique functions and distinct gene-expression signatures. While it has been established that they originate mostly from embryonic progenitor cells, the signals that induce a characteristic tissue-specific differentiation program remain unknown. We found that the nuclear receptor PPAR-γ determined the perinatal differentiation and identity of alveolar macrophages (AMs). In contrast, PPAR-γ was dispensable for the development of macrophages located in the peritoneum, liver, brain, heart, kidneys, intestine and fat. Transcriptome analysis of the precursors of AMs from newborn mice showed that PPAR-γ conferred a unique signature, including several transcription factors and genes associated with the differentiation and function of AMs. Expression of PPAR-γ in fetal lung monocytes was dependent on the cytokine GM-CSF. Therefore, GM-CSF has a lung-specific role in the perinatal development of AMs through the induction of PPAR-γ in fetal monocytes.
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