环戊烷
立体化学
戒指(化学)
化学
IC50型
IRIS(生物传感器)
植物
生物
生物化学
有机化学
体外
计算机科学
人工智能
生物识别
作者
Chunlei Zhang,Zhi‐You Hao,Yanfei Liu,Yan Wang,Guo-Ru Shi,Zhibo Jiang,Ruo-Yun Chen,Zhengyu Cao,De‐Quan Yu
标识
DOI:10.1021/acs.jnatprod.6b00796
摘要
Six new iridal-type triterpenoids containing an unprecedented cyclopentane ring, polycycloiridals E–J (1–6), were isolated from a large-scale re-extraction of Iris tectorum. A possible biosynthesis pathway is postulated. The known spirioiridotectal D (7) was also obtained in the current investigation, and its structure was unequivocally defined using X-ray diffraction data. Compound 7 suppressed LPS-activated NO production in the BV2 cell line with an IC50 value of 0.54 μM.
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