生物制药分类系统
生物制药
前药
生物利用度
溶解度
化学
膜透性
渗透
磁导率
生化工程
水溶液
药品
组合化学
限制
膜
药理学
有机化学
生物化学
工程类
医学
生物活性
体外
生药学
机械工程
作者
Vivek S Dave,Divender Gupta,Monica Yu,Phung Kim Phi Nguyen,Sheeba Varghese Gupta
标识
DOI:10.1080/03639045.2016.1269122
摘要
The Biopharmaceutics Classification System (BCS) classifies pharmaceutical compounds based on their aqueous solubility and intestinal permeability. The BCS Class III compounds are hydrophilic molecules (high aqueous solubility) with low permeability across the biological membranes. While these compounds are pharmacologically effective, poor absorption due to low permeability becomes the rate-limiting step in achieving adequate bioavailability. Several approaches have been explored and utilized for improving the permeability profiles of these compounds. The approaches include traditional methods such as prodrugs, permeation enhancers, ion-pairing, etc., as well as relatively modern approaches such as nanoencapsulation and nanosizing. The most recent approaches include a combination/hybridization of one or more traditional approaches to improve drug permeability. While some of these approaches have been extremely successful, i.e. drug products utilizing the approach have progressed through the USFDA approval for marketing; others require further investigation to be applicable. This article discusses the commonly studied approaches for improving the permeability of BCS Class III compounds.
科研通智能强力驱动
Strongly Powered by AbleSci AI