嘌呤能受体
嘌呤能信号
细胞生物学
胞吐
三磷酸腺苷
分泌物
泛连接蛋白
生物
腺苷
受体
化学
腺苷受体
连接蛋白
生物化学
细胞内
细胞外
缝隙连接
兴奋剂
作者
Geoffrey Burnstock,Gillian E. Knight
标识
DOI:10.1007/s00441-017-2618-8
摘要
There is abundant evidence that ATP (adenosine 5'-triphosphate) is released from a variety of cultured cells in response to mechanical stimulation. The release mechanism involved appears to be a combination of vesicular exocytosis and connexin and pannexin hemichannels. Purinergic receptors on cultured cells mediate both short-term purinergic signalling of secretion and long-term (trophic) signalling such as proliferation, migration, differentiation and apoptosis. We aim in this review to bring to the attention of non-purinergic researchers using tissue culture that the release of ATP in response to mechanical stress evoked by the unavoidable movement of the cells acting on functional purinergic receptors on the culture cells is likely to complicate the interpretation of their data.
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