代谢组
水蚤
代谢物
代谢组学
大型水蚤
银纳米粒子
化学
生物
代谢途径
新陈代谢
毒性
食品科学
生物化学
生态学
甲壳动物
色谱法
有机化学
材料科学
纳米技术
纳米颗粒
作者
Bo Zhang,Hui Zhang,Cheng-Ran Du,Qin Xiang Ng,Chaoyang Hu,Yiliang He,Choon Nam Ong
标识
DOI:10.1016/j.watres.2017.02.046
摘要
Silver nanoparticles (AgNPs) are one of the most widely used nanomaterials. Their fast-growing utilization has increased the occurrence of AgNPs in the environment, posing potential health and ecological risks. In this study, we conducted chronic toxicity tests and investigated the metabolic changes of the growing Daphna similis with exposure to 0, 0.02, and 1 ppb AgNPs, using non-targeted mass spectrometry-based metabolomics. To the best of our knowledge, this study is the first to report the baseline metabolite change of a common aquatic organism Daphnia crustacean through its life-cycle. The results show a dynamic kinetic pattern of the growing Daphnia's metabolome underwent a cycle from day 0 to day 21, with the level of metabolites gradually increasing from day 0 to day 13, before falling back to the baseline level of day 0 on day 21. As for the samples exposed to environmental concentrations of AgNPs, although without morphological or structural changes, numerous metabolite changes occurred abruptly during the first 10 days, and these changes reached steady state by day 13. The significant changes in certain metabolites, such as amino acids (serine, threonine and tyrosine), sugars (d-allose) and fatty acids (arachidonic acid) revealed new insights into how these metabolites in Daphnia respond to chronic AgNPs stress. These findings highlight the capability of metabolomics to discover early metabolic responses to environmental silver nanoparticles.
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