药物输送
药品
中止
医学
药理学
剂型
材料科学
控制释放
纳米技术
生物医学工程
靶向给药
外科
作者
Lissette Agüero,Dionisio Zaldivar Silva,Luis Peña,Marcos L. Dias
标识
DOI:10.1016/j.carbpol.2017.03.033
摘要
The increase in the research interest on alginate microparticles in pharmaceutical and biomedical areas confirms its potential use as an effective matrix for drug and cell delivery. Among the well known alginate properties, pH sensitivity remains as an attractive option for targeting of drug in the colon region. This essential aspect is advantageous to enhance therapeutic efficacy of treatment of inflammatory bowel diseases, which require multi-drug administration frequently in a long period. As consequence, severe side effect appears leading to discontinuation of therapy and affecting quality of patient life. This review gives an overview of relevant properties of alginate as oral colon delivery systems and the recent innovative strategies of using alginate with other polymers as well as microencapsulation techniques. At the same time, it describes the several advantages of coating processes involving alginate over microparticles in order to design better material with sustained release characteristic for colon-targeted delivery.
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