免疫组织化学
间质细胞
三阴性乳腺癌
组织微阵列
乳腺癌
乳腺癌
肿瘤浸润淋巴细胞
病理
医学
组织学
淋巴结
基质
癌
转移
癌症研究
癌症
内科学
免疫疗法
作者
W Zhang,Guang Xu,J J Li,X Liu,Y J Chen,F Zhang
出处
期刊:PubMed
日期:2017-01-08
卷期号:46 (1): 20-24
被引量:1
标识
DOI:10.3760/cma.j.issn.0529-5807.2017.01.005
摘要
Objective: To investigate the correlation between the expression of PD-1, PD-L1 and clinicopathologic parameters in triple negative breast carcinoma (TNBC). Methods: Samples from 151 patients with TNBC and 65 cases of other breast carcinomas (non-TNBC) were examined for PD-L1 and PD-1 expression by immunohistochemical staining on tissue microarray. Results: The expression of PD-L1 and PD-1 in the tumor cells and interstitial lymphocytes in TNBC was significantly (P<0.05)higher than that in non-TNBC.In TNBC, the expression rates of PD-L1 in the cancer nests and stroma were 16.6%(25/151) and 25.2%(38/151)respectively.The former was positively correlated with tumor histological grade and lymph node metastasis (P<0.05), and the latter only with tumor histological grade (P<0.05). The expression rate of PD-1 was 27.2% (41/151), and correlated with PD-L1 expression in stromal tumor-infiltrating lymphocytes (P<0.05). Conclusion: The expression of PD-L1 in TNBC is significantly correlated with high-grade histology, lymph node metastasis and PD-L1 expression in stromal tumor-infiltrating lymphocytes.
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