Targeted therapy and its application on gastrointestinal stromal tumor

Targeted therapy has gradually become the focus in the treatment of tumor,with the emerge of more and more targeted drugs which has brought the treatment of tumor into a new era.Imatinib,the tyrosine kinase inhibitor,is one of the important types of targeted therapy,has become the standard of care in adjuvant therapy of gastrointestinal stromal tumor(GIST) with extraordinary effects.However,the questions are still on debate incluing the optimal way to evaluate treatment results,the treatment duration,whether it can be intermitted or not,second line therapy for imatinibintolerance or-resistance and the combination with surgery.