化学
对映选择合成
立体中心
分子内力
赫克反应
催化作用
钯
有机化学
组合化学
作者
Chong Shen,Renrong Liu,Ren‐Jie Fan,Yinglong Li,Tengfei Xu,Jianrong Gao,Yi‐Xia Jia
摘要
A highly enantioselective intramolecular arylative dearomatization of indoles via palladium-catalyzed reductive Heck reactions was developed. The new strategy led to a series of optically active indolines bearing C2-quaternary stereocenters in modest to good yields with excellent enantioselectivities (up to 99% ee).
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