Objective To observe the recent therapeutic effects of small incision minimally invasive transforaminal lumbar interbody fusion(TLIF) on single segmental lumbar degenerative disease.Methods 120 patients with single segmental lumbar degenerative disease were randomly divided into 2 groups,60 eases in the control group took traditional open transforaminal lumbar inter-body fusion treatment,observation group of 60 cases received minimally invasive transforaminal lumbar inter-body fusion treatment,compared 2 groups of patients' JOA score and evaluated the life quality of patients with lumbar spine.Results Observation group patients' operation time is longer than that of the control group[(149.3 ±23.2) min vs.(128.4 ±24.7) min,P 0.05],but its operation blood loss,length of incision and the average days of hospitalization were significantly lower than that of control group(P 0.05);2 months after treatment,the observation group patients quality of life score was significantly higher than that in control group[(75.4 ±8.2) points vs.(59.5 ±7.7) points,P 0.05],JOA scores of the 2 groups were all improved(P 0.05),and the lumbar JOA in observation group after treatment was also higher than that of the control group[(26.6 ± 2.8) points vs.(18.5±2.4) points,P 0.05].Conclusion Effect of minimally invasive small incision transforaminal lumbar interbody fusion lor the treatment ol single segment lumbar degenerative diseases is good,worthy of clinical choice.