Physical-mathematic model is built for the process of evaporation and combustion of the two interactive arbitrary size semisphere pearly transpiration droplets in platelet hole structure under micro-gravity condition. Bispherical coordinates are applied in calculating the two transpiration droplets’ distribution and the evaporation and combustion rate. Analytic solutions for the distributions and the interactive factors of the two transpiration droplet are obtained. Evaporation rate and combustion rate of the two interactive transpiration droplets are calculated under different conditions.