红细胞痛
医学
钠通道阻滞剂
钠通道
神经病理性疼痛
感觉系统
神经科学
麻醉
心理学
钠
化学
有机化学
作者
Lishuang Cao,Aoibhinn McDonnell,Anja Nitzsche,Aristos J. Alexandrou,Pierre‐Philippe Saintot,Alexandre Loucif,Adam R. Brown,Gareth T. Young,Malgorzata A. Mis,Andrew D. Randall,Stephen G. Waxman,P Stanley,Simon Kirby,Sanela Tarabar,Alex Gutteridge,Richard P. Butt,Ruth M. McKernan,Paul J. Whiting,Zahid Ali,James Bilsland
标识
DOI:10.1126/scitranslmed.aad7653
摘要
A selective Nav1.7 sodium channel blocker reduced hyperexcitability of iPSC-derived sensory neurons and alleviated pain in a subpopulation of patients with an inherited pain disorder.
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