Objective:To observe and summarize the clinical effect of endoscopic nasal septum surgery combined with multi-sinus surgery, and to discuss the safety and feasibility. Methods: Eighty patients with nasal sinues and nasal cavity diseases received endosopic nasal septal reconstruction, polypectomy, ethmoidectomy and partial middle or inferior turbinate resection simultaneously under local anesthesia, and the complications after surgery were observed. Results: Operations in eighty patients were completed successfully.Fifty-five cases were cured, the cure rate of 80 cases was 72.5%, 19 cases effectively recovered (23.75%), and 3 cases didn't recover (3.75%).The clinical cure rate was 96.25%.No severe complications occured. Conclusion: The nasal septal surgery combined with endoscopic nulti-sinus surgery simultaneously under local anesthesia is an effective and safety procedure.It can decrease the recurrence rate of nasal polyp and sinusitis and don't increase the incidence of complication.