Study the effects of nitric oxide and endothelin-1 on the formation of pulmonary edema in the patients with acute organic phosphorus intoxication

Objective To study the effects of nitric oxide(NO) and endothelin-1(ET-1) on the formation of pulmonary edema in the patients with acute organic phosphorus intoxication(AOPI).Methods Plasma NO and ET-1 were tested with reductive Griess and radioimmuno assay for the AOPI patients before,in and after suffering from pulmonary edema respectively.Results ET-1 was rised in AOPI patients and it was more significant(P0 01) while suffering from pulmonary edema, there was no significant defference compared with control before pulmonary edema;NO was higher before pulmonary edema,and it was low during pulmonary edema,the change was more significant (P0 01) after comparing with control.It became higher(P0 05) after pulmonary edema,and compared with control (P0 05).Conclusion The cytotoxity and reduction of NO intensified the effects of endothelin on the blood vessels,which was an important factor for the formation of AOPI pulmonary edema.So it would play an important role in AOPI pulmonary edema to inspire low density NO in the process of treatment.