Detection and clinical significance of sICAM-1 in type 2 diabetic patients with microalbuminuria

Objective: To observe the level of plasma soluble intercellular adhesion molecule 1(sICAM-1) and relationship of sICAM-1 and urinary albumin excretion rate(UAER) in type 2 diabetic patients with microalbuminuria.Methods: The levels of plasma sICAM-1 and UAER in 30 healthy subjects(control group),30 type 2 diabetic patients with microalbuminuria and 28 type 2 diabetic patients without albuminuria were measured by ELISA and radioimmunoassay(RIA) respectively. Results: The level of plasma sICAM-1 in type 2 diabetic patients without albuminuria was significantly higher than that in control group(P0.05),the level of sICAM-1 in type 2 diabetic patients with microalbuminuria was significantly higher than that in group without albuminuria(P0.01),the level of sICAM-1 was positively correlated with that of UAER in type 2 diabetic patients(r=0.53,P0.01),especially in microalbuminuric patients(r=(0.59),P0.01). Conclusion: An enhanced level of plasm sICAM-1 may be involved in the occurrence and development of type 2 diabetic microalbuminuria,the detection of it can be served as a clinical index of the diagnosis,therapy and prognosis of early diabetic nephropathy.