Analysis on the levels of serum adiponectin and the effect of atorvastatin intervention in heart failure patients.

Objective To explore the effect of atorvastatin intervention in the treatment of heart failure patients,and to analyze the levels of serum adiponectin.Methods Sixty patients with congestive heart failure admitted to our hospital from January 2011 to June 2012 were selected,which were randomly divided into the study group and the control group,with 30 patients in each group.The two groups were both were given conventional treatment,and the study group added atorvastatin statin 20 mg,once daily for 3 months.The levels of APN were detected before and after treatment using enzyme-linked immunosorbent assay,and the left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD) were detected by ultrasound ECG.Results ① Among the 60 patients,APN levels in patients with grade Ⅱ,Ⅲ,IV cardiac function were(5.71±1.85) mg/L,(11.08±2.78) mg/L and(15.08±3.72) mg/L,respectively.The APN levels in patients with heart failure increased gradually with deteriorating of cardiac function(P0.01).② Before treatment,APN,LVEF,LVEDD showed no significant difference between the two groups(P0.05).After treatment,LVEF was significantly increased,while LVEDD,APN significantly decreased(P0.05).After treatment,LVEF in the study group was higher than that of the control group,while LVEDD,APN in the study group were lower.APN after intervention was significantly lower than that before intervention(P0.05).Conclusion The serum adiponectin levels in chronic heart failure patients are abnormally elevated,and gradually increased with the deterioration of cardiac function in patients.The atorvastatin intervention can improve heart function in patients and lower the serum adiponectin levels.