材料科学
生物医学工程
再生(生物学)
生物相容性材料
自愈水凝胶
组织工程
弹性体
软组织
组织扩张
再生医学
纳米技术
聚合物
肿胀 的
3D生物打印
生物相容性
3D打印
软物质
3d打印
造型(装饰)
复合材料
软骨
各向同性
仿生材料
球体
作者
Ruijue Cao,Guancong Chen,Linhong Wang,Wang Wang,Chujun Ni,Zhuoheng Xia,Anni Hu,Wei Hu,Hai-Lu Lin,Pengxu Qian,Fan Yang,Qian Zhao
标识
DOI:10.1002/adma.202512662
摘要
Abstract Controllable tissue expansion is critical in regenerative medicine to address skin or mucosal defects. Tissue expanders based on isotropic water filling or swelling offer a clinical solution but face challenges in addressing individual anatomical complexities. Here, a 4D printing biocompatible hydrogel expander with customizable designs is reported. Water‐swellable polymer sheets with non‐swellable elastomer frameworks are synthesized via digital photocuring. The sheets buckle upon adsorption of tissue fluids to execute anisotropic and programmable morphing, forming predesigned 3D structures with time as the fourth dimension for the shape changing. With an initial thickness of 1.0 mm, which is remarkably thinner than previous devices (typically 3–5 mm), the expander enabled minimally invasive implantation in the rat scalp. After 5 days’ implantation, the skin area and weight respectively increase to two and three folds without tissue damage, illustrating that the buckling‐based strategy provides a safer yet accelerated expansion effect over previous devices. RNA sequencing indicates that the buckling‐induced regeneration involving epithelial‐to‐mesenchymal transition (EMT) may be affected by the PI3K‐AKT pathway. This work provides an inspiring strategy for personalized regeneration medicine.
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