Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4‐ and VEGF‐mediated pathways: insights from a vascular to mixed‐type dementia model

CCH impairs glymphatic function through AQP4 depolarization and VEGF suppression, causing toxic protein accumulation. Restoring vascular tone rescued cognition, establishing a mechanistic link between vascular dysfunction and neurodegeneration in cognitive impairment.