染色质
生物
免疫系统
基因
遗传学
电池类型
计算生物学
数量性状位点
疾病
细胞
进化生物学
外周血
基因表达调控
基因调控网络
表型
嘉雅宠物
人类遗传学
染色质重塑
基因表达
全基因组关联研究
作者
Jianhua Yin,Yuhui Zheng,Zhuoli Huang,Wenwen Zhou,Yue Yuan,Pengfei Cai,Yong Bai,Shichen Yang,Yue Gao,Shanshan Duan,Yang Wang,Zekai Xu,W H Zhang,Xinyu Zhang,Yilin Wei,Yaling Huang,Ying Liu,Weikai Wang,Tao Yang,Zhongjin Zhang
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2026-01-08
卷期号:391 (6781): eadt3130-eadt3130
被引量:11
标识
DOI:10.1126/science.adt3130
摘要
Human peripheral blood exhibits molecular and cellular heterogeneity across populations, yet the underlying mechanisms remain unclear. We present the Chinese Immune Multi-Omics Atlas (CIMA), characterizing molecular variations linked to sex, age, and genetic variants through multi-omics analysis of more than 10 million circulating immune cells from 428 Chinese adults. CIMA established an enhancer-driven gene regulatory network comprising 237 robust regulons; identified 9600 eGenes and 52,361 caPeaks at cell type resolution; and revealed pleiotropic associations among immune-related disease risk loci, cis-expression quantitative trait loci (QTLs), and chromatin accessibility QTLs. Furthermore, the cell language model CIMA-CLM predicted chromatin accessibility and evaluated the effects of noncoding variants from chromatin sequences and gene expression. CIMA provides a comprehensive reference for immune-related disease research.
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