Inflammaging and oral diseases: New sights from pathology to therapeutic consideration

Population aging intensifies age-related oral diseases, severely damaging systemic health. Central to this is inflammaging, driven by interconnected mechanisms (immunosenescence, cellular senescence, and metabolic senescence), which leads to a chronic inflammatory state. The pathogenesis of periodontitis, oral mucosal disorders and malignant transformation, dental pulp degeneration, and temporary mandibular joint diseases are related to inflammaging in the context of systemic degeneration. Targeting therapies include reversing inflammaging and merely improving outcomes under an inflammaging background, thereby advancing geriatric oral healthcare, and preserving both oral function and systemic vitality.