Programmable Biohybrid Probiotics with Long‐Term Storage Stability for Enhanced Intestinal Microbiota Regulation and Ulcerative Colitis Treatment

chelation in inflamed colonic tissue, thereby achieving spatiotemporally controlled bacterial activation and drug release. Guided by UC transcriptomic signatures, this combinatorial design concurrently targets immune dysregulation and microbial imbalance. In a dextran sulfate sodium-induced murine UC model, Bif@FCSM(A) markedly alleviated disease severity, suppressed pro-inflammatory cytokines, restored mucosal immune homeostasis, and enriched short-chain fatty acid-producing taxa. This work establishes a programmable, pathology-responsive probiotic platform with translational potential for complex inflammatory diseases.