Supramolecular janus eutectic engineered from panthenol and bisabolol overcomes transdermal delivery paradoxes

Abstract Conventional transdermal delivery systems are constrained by inherent trade-offs among penetration efficiency, bioactive potency, and skin biocompatibility. To overcome these limitations, we report a supramolecular Janus eutectic engineered from D-panthenol and α-(-)-bisabolol (SPB). This carrier-free system uniquely integrates autonomous permeation with multimodal therapeutic functions. SPB demonstrates synergistic enhancement of panthenol transdermal delivery while markedly improving the biocompatibility of bisabolol, alongside multiplex anti-irritation and pro-repair efficacy—a combination unattainable by its individual components or physical mixtures. Mechanistic investigations indicate that the supramolecular architecture modulates the active transport pathway and antagonizes the TRPV1 receptor. This work provides a paradigm for designing biofunctional materials that intrinsically unify delivery, efficacy, and safety.