Determination of bisphenol S in food and drink take away packaging by LC-MS/MS

Food packaging is a key part within the food safety. The components of these food contact materials should be studied with great caution because they can migrate to the food depending on several factors. Many of these food containers are made of materials such as polycarbonates or paper and cardboard. These polymeric materials can decompose at high temperatures and bisphenolic compounds, such as bisphenol S, can migrate from the contact material to the food. It is suspected that Bisphenol S is a Bisphenol A substitute and an endocrine disrupter with potential acute toxicity, genotoxicity and estrogenic activity, even in very low concentration on the order of tens to hundreds of nanograms per kilogram body weight. In this work, a method by liquid chromatography coupled to a triple quadrupole mass spectrometer (LC-MS/MS) has been developed for the analysis of bisphenol S in different cardboard take away packaging of food and drinks without any sample preparation step. The analyte was separated on a Kinetex C18 (100 × 2.1 mm, 2.6 μm size of particle) column and using methanol: water as mobile phase. The proposed method exhibited an appropriate sensitivity with a limit of detection of 1 µg/L, good linearity and the analysis is completed in only 3 min.