Predicting chemotherapy toxicity in older adults: Methodological issues

We were interested to read the paper by Moth EB and colleagues published in Sep 2018 issue of the J Geriatr Oncol [ [1] Moth E.B. Kiely B.E. Stefanic N. Naganathan V. Martin A. Grimison P. et al. Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. J Geriatr Oncol. 2018; https://doi.org/10.1016/j.jgo.2018.08.010 Abstract Full Text Full Text PDF Scopus (25) Google Scholar ]. The purpose of the authors were to evaluate the Cancer and Aging Research Group's (CARG) Score for predicting severe chemotherapy-related toxicity in an external population of older adults, and compare it to the predictive value of oncologists' estimates of the risk of severe toxicity, also to determine the ability of the CARG Score to predict for all-grade toxicities and to identify predictors of severe toxicity using a brief geriatric assessment (GA). For this, CARG toxicity score of 126 patients calculated with solid organ cancer prospectively [ [1] Moth E.B. Kiely B.E. Stefanic N. Naganathan V. Martin A. Grimison P. et al. Predicting chemotherapy toxicity in older adults: Comparing the predictive value of the CARG Toxicity Score with oncologists' estimates of toxicity based on clinical judgement. J Geriatr Oncol. 2018; https://doi.org/10.1016/j.jgo.2018.08.010 Abstract Full Text Full Text PDF Scopus (25) Google Scholar ].