胶质细胞源性神经生长因子
哈姆德
神经营养因子
内科学
萧条(经济学)
重性抑郁障碍
医学
脑源性神经营养因子
评定量表
心理学
汉密尔顿焦虑量表
胃肠病学
肿瘤科
焦虑
精神科
显著性差异
受体
发展心理学
经济
扁桃形结构
宏观经济学
作者
Jiaze Sun,Lingtao Kong,Feng Wu,Yange Wei,Yue Zhu,Zhiyang Yin,Xin Deng,Xiaowei Jiang,Yanqing Tang,Fei Wang
标识
DOI:10.1016/j.jad.2018.11.068
摘要
Glial cell line-derived neurotrophic factor (GDNF) as a neurotrophic factor closely related to depression is able to promote the growth, proliferation, differentiation, and survival of multiple neurons. Clinical features, recurrence rates and suicide rates are significant different in major depressive disorder (MDD) according to age. GDNF level changes in the peripheral blood has been reported in patients with MDD. In this study, we aimed to investigate whether GDNF levels differentiated within various age groups and its relationship with age/clinical severity.MDD subjects and healthy controls (HC) are divided into younger (age 13-24 years) group (yMDD n = 35, yHC n = 44) and older (age 25-45 years) group (oMDD n = 30, oHC n = 55) based on the age of brain maturity. Clinical symptom severity was evaluated by the Hamilton Depression Rating Scale (HAMD-17) and the Hamilton Anxiety Rating Scale (HAMA-17). The levels of plasma GDNF were compared within subgroups.Plasma GDNF levels in yMDD patients were significantly decreased compared to yHC (yMDD 1.55 ± 0.46pg/ml, yHC 1.77 ± 0.47pg/ml, p < 0.05). Moreover, such difference was not found between oMDD group and oHC group. Our results also showed negative correlations between plasma GDNF levels and HAMD/HAMA scores (r = -0.33, p < 0.05; r = -0.39, p < 0.05).This study was underpowered to observe dynamic changes between age and GDNF in MDD due to the cross-sectional design of present study. We also failed to divided subjects into more age groups because of moderate sample size.The present result showed the level of protective neurotrophic factor GDNF associated with age in MDD, suggesting a relevance between GDNF and MDD subjects abnormal brain development in adolescent and young adult period.
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