先天性淋巴细胞
免疫系统
生物
有机体
效应器
平衡
受体
先天免疫系统
细胞生物学
分泌物
神经科学
免疫学
生物化学
古生物学
作者
Cyril Seillet,Nicolas Jacquelot
标识
DOI:10.1038/s41423-019-0217-1
摘要
Maintenance of homeostasis and immune protection rely on the coordinated action of different physiological systems. Bidirectional communication between the immune system and physiological systems is required to sense and restore any disruption of equilibrium. Recent transcriptomic analyses of innate lymphoid cells (ILCs) from different tissues have revealed that ILCs express a large array of receptors involved in the recognition of neuropeptides, hormones and metabolic signals. ILCs rapidly secrete effector cytokines that are central in the development and activation of early immune responses, but they also constitutively secrete mediators that are important for tissue homeostasis. To achieve these functions effectively, ILCs integrate intrinsic and extrinsic signals that modulate their constitutive and induced activity. Disruption of the regulation of ILCs by physiological regulators leads to altered immune responses with harmful consequences for the organism. An understanding of these complex interactions between the immune system and physiological mediators is crucial to decipher the events leading to the protective versus pathological effects of these cells.
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