Gold(III)‐Catalyzed Intermolecular Oxidation‐Cyclization of Ynones: Access to 4‐Substituted Chroman‐3‐ones

Abstract A synthesis of 4‐substituted chroman‐3‐one derivatives has been developed through a gold(III) catalyzed oxidation‐cyclization of ynones in good to excellent yield using easily prepared substrates. A broad range of synthetically useful functional groups (halide, alkene, alkyne, phenolic hydroxyl) were tolerated. Further application of this method paves a new way to prepare the skeleton of oblarotenoids. A cascade oxidative cyclization for construction of pyrano[2,3‐c]chromen‐1(5H)‐one derivatives is also presented. magnified image