木脂素
化学
花椒
化学成分
IC50型
传统医学
立体化学
体外
生物化学
色谱法
生物
植物
医学
出处
期刊:China journal of Chinese materia medica
[China Journal of Chinese Materia Medica]
日期:2015-07-15
被引量:2
标识
DOI:10.4268/cjcmm20151429
摘要
To study the chemical constituents from Zanthoxylum simulans and their anti-inflammatory activity. The constituents of Z. simulans were isolated and purified using various column chromatographies. Their chemical structures were elucidated using extensive spectroscopic methods. The compounds were assayed inhibitory activity against NO production in LPS stimulated RAW 264.7 cells. Four compounds were obtained from the ethanol extract of Z. simulans and determined to be isozanthpodocarpin B(1), kobusin (2), (+)-fargesin (3), and epieudesmin (4). Compound 1 exhibited NO production inhibitory effect with IC50 value of 14.49 µmol · L(-1). Compound 1 is a new dimeric lignan and may be serve as potential anti-inflammatory agent in the future.
科研通智能强力驱动
Strongly Powered by AbleSci AI