This study examined the distribution of diabetic medications among adults with type 2 diabetes, and the association between glucose control and treatment approach. During 1999–2004, approximately 60 percent of adults with type 2 diabetes used only oral agents to manage their diabetes. Use of multiple oral agents among adults with type 2 diabetes has increased. However, nearly half of adults with type 2 diabetes have HbA1c levels above guidelines for control, indicating that available treatments could be used more optimally, and new diabetic agents may be needed.