Sub‐Chronic Effects of Orally Ingested Liquid Dietary Supplement, TAIslim® Containing A Combination of Soluble Dietary Fiber, Phenylalanine, N‐Acetyl‐Tyrosine, Tea Polyphenols with Caffeine and Lycium barbarum on Body Weight and Other Anthropometric Parameters in a Controlled Cross‐over Human Clinical Study

Three month intake of TAI slim ® containing soluble dietary fiber, L‐phenylalanine, N‐acetyl‐L‐tyrosine, standardized tea polyphenols with caffeine and Lycium barbarum was examined in a controlled human clinical study in a cross‐over design. Total 25 healthy overweight adults (age=40.7 y, BMI=29.9 kg/m 2 ) consumed 60 ml of TAI slim 3 times/d immediately before meals. Anthropometric parameters and resting metabolic rate (RMR) measured by an indirect calorimeter were examined at baseline, on 30, 60 and 90 days in both phases. The phase interval was 60 days. Subjects were required to walk 30 min daily monitored by pedometer and to curtail caloric intake after 7 PM. A protein‐based diet with multi‐vitamin and Lycium barbarum supplement resume program (about 1,200 kcal/d) was required and monitored by diary. Average parameters were significantly reduced by 6.3% (body weight), 6.1% (BMI), 7.4% (waist circumference), 5.4% (waist/hip ratio), 5.4% (total body fat), 14.5% (fasting blood glucose level), blood pressure (SBP by 8.4%, DBP by 14.3%) and heart rate by 7.2% (P < 0.05) from pre‐intervention. RMR was significantly increased by 220 kcal, about 14% over baseline (1,679 kcal) 2h after TAI slim intake. To the contrary, during the control phase, all parameters were not significantly changed compared to the baseline. These results suggest that TAI slim may affect anthropometric parameters by enhancing energy expenditure.