生物
极性(国际关系)
细胞生物学
秀丽隐杆线虫
信号转导衔接蛋白
上皮极性
顶膜
网格蛋白
电池极性
生物化学
信号转导
内吞作用
膜
受体
基因
细胞
作者
Huanhu Zhu,Aileen K. Sewell,Min Han
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2015-06-15
卷期号:29 (12): 1218-1223
被引量:35
标识
DOI:10.1101/gad.263483.115
摘要
TORC1 (target of rapamycin complex 1) plays a central role in regulating growth, development, and behavior in response to nutrient cues. We previously showed that leucine-derived monomethyl branched-chain fatty acids (mmBCFAs) and derived glucosylceramide promote intestinal TORC1 activity for post-embryonic development and foraging behavior in Caenorhabditis elegans . Here we show that clathrin/adaptor protein 1 (AP-1)-dependent intestinal apical membrane polarity and polarity-dependent localization of the vacuolar-type H + -ATPase (V-ATPase) mediate the impact of the lipid pathway on intestinal TORC1 activation. Moreover, NPRL-3 represses mmBCFA-dependent intestinal TORC1 activity at least partly by regulating apical membrane polarity. Our results provide new insights into TORC1 regulation by lipids and membrane polarity in a specific tissue.
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