Urinary hydroxylysine and hydroxylysyl glycoside excretions in normal and pathologic states.

Hydroxylysyl glycoside excretion in the urine of normal subjects and of patients having either a skin or a bone disease was measured by ion exchange chromatography. Free hydroxylysine and peptide-bound hydroxylysine excretions were determined in normal and certain pathologic urines. Hydroxylysyl glycosides constitute the greatest fraction of the total hydroxylysine excretion (81 per cent). The monosaccharidic form predominates in the urine of patients with bone diseases, while the disaccharidic form is mainly excreted in skin diseases. Free hydroxylysine and peptide-bound hydroxylysine represent, respectively, 8 and 11 per cent of the total hydroxylysine excretion. Most of this latter form comes probably from large urinary polypeptides. In some diseases, smaller peptides containing hydroxylysine could be released. © 1974.