Mesh stiffness always is a studying focus of gear dynamics. In the issue, a solution for the calculation of mesh stiffness considering the sliding friction effect is constructed, and the influence of the sliding friction on mesh stiffness is analyzed. Further, the analytical results indicate mesh stiffness is sensitive to the sliding friction in poorly lubricating conditions specially. These contributions would not only simplify the calculation of mesh stiffness associated with the sliding friction but also be good for assessing the dynamic behaviors of spur gear drives in some special operating conditions