生物利用度
药理学
药品
药代动力学
化学
药效学
药物发现
医学
生物化学
作者
Abid Naeem,Ming Yang,Peng-Yi Hu,Kang Yong Jie,Yali Liu,Haiyan Zhang,Shan Xiao,Wenjing Li,Lijun Wu,Zhang Ming Xia,Liu Shan Shan,Qi Zheng
标识
DOI:10.1080/10408398.2021.1898333
摘要
Despite advancements in synthetic chemistry, nature remains the primary source of drug discovery, and this never-ending task of finding novel and active drug molecules will continue. Flavonoids have been shown to possess highly significant therapeutic activities such as anti-inflammatory, anti-oxidant, anti-viral, anti-diabetic, anti-cancer, anti-aging, neuroprotective, and cardioprotective, etc., However, it has been found that orally administered flavonoids have a critical absorption disorder and, therefore, have low bioavailability and show fluctuating pharmacokinetic and pharmacodynamic responses. A detailed investigation is required to assess and analyze the variation in the bioavailability of flavonoids due to interactions with the intestinal barrier. This review will emphasize on the bioavailability and the pharmacological applications of flavonoids, key factors affecting their bioavailability, and strategies for enhancing bioavailability, which may lead to deeper understanding of the extent of flavonoids as a treatment and/or prevention for different diseases in clinics.
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