下调和上调
小RNA
小干扰RNA
化学
细胞凋亡
基因沉默
细胞
细胞生长
癌细胞
作者
Wenkuan Chen,Jianchang Fu,Yingle Chen,Yudong Li,Li Ning,Dou Huang,Shumei Yan,Quan Zhang
出处
期刊:Aging
[Impact Journals, LLC]
日期:2021-06-21
卷期号:13 (12): 16500-16512
被引量:3
标识
DOI:10.18632/aging.203172
摘要
Circular RNAs (circRNAs) are one type of non-coding RNA. They act as important role in regulating various biological processes in the malignant progression. But we don't clearly know the specific mechanism of the majority circRNAs in papillary thyroid tumor progression. In the current study, we explored circKIF4A and the result showed that it had high expression in papillary thyroid cancer. The functions of circKIF4A were explored by CCK-8, transwell, and mouse xenograft experiments. Knockdown of circKIF4A could suppress papillary thyroid cell growth and migration. In addition, RIP assays and dual luciferase vector reporter assays were further conducted. Our consequence showed circKIF4A facilitated the malignant progress of papillary thyroid tumor by sponging miR-1231 and upregulating GPX4 expression. In conclusion, our study proved that circKIF4A-miR-1231-GPX4 axis played a vital role in cancer proliferation and ferroptosis by competing endogenous RNAs. Therefore, targeting circKIF4A is very likely to be a potential method for treatment of papillary thyroid cancer in the future.
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