胶质瘤
表观遗传学
医学
突变体
再生(生物学)
放射治疗
转化研究
癌症研究
生物信息学
病理
生物
内科学
基因
遗传学
作者
Davis P. Argersinger,Sarah Rivas,Ashish H. Shah,Sadhana Jackson,John D. Heiss
出处
期刊:Cancers
[MDPI AG]
日期:2021-10-21
卷期号:13 (21): 5280-5280
被引量:28
标识
DOI:10.3390/cancers13215280
摘要
H3K27M-mutant diffuse midline gliomas (DMGs) are rare childhood central nervous system tumors that carry a dismal prognosis. Thus, innovative treatment approaches are greatly needed to improve clinical outcomes for these patients. Here, we discuss current trends in research of H3K27M-mutant diffuse midline glioma. This review highlights new developments of molecular pathophysiology for these tumors, as they relate to epigenetics and therapeutic targeting. We focus our discussion on combinatorial therapies addressing the inherent complexity of treating H3K27M-mutant diffuse midline gliomas and incorporating recent advances in immunotherapy, molecular biology, genetics, radiation, and stereotaxic surgical diagnostics.
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