鼻咽癌
表皮生长因子受体
癌症研究
单克隆抗体
医学
放射治疗
头颈部癌
信号转导
癌
爱泼斯坦-巴尔病毒
肿瘤科
病毒
受体
生物
免疫学
抗体
内科学
生物化学
作者
Efthymios Kyrodimos,Aristeidis Chrysovergis,Nicholas S Mastronikolis,Evangelos Tsiambas,Vasileios Ragos,Dimitrios Roukas,Panagiotis P Fotiades,Vasileios Papanikolaou
出处
期刊:Journal of B.U.ON. : official journal of the Balkan Union of Oncology
日期:2021-05-01
卷期号:26 (3): 759-761
被引量:1
摘要
Nasopharyngeal carcinoma (NPC) represents a specific, aggressive pathological entity included in the Head and Neck Carcinoma (HNC) family of malignancies. NPC is derived from the nasopharyngeal epithelia expressing a high invasive and metastatic potential affecting negatively patients' prognosis due to poor survival rates. Concerning pathogenetic factors implicated in its rise and progression, Epstein-Barr virus (EBV) latent but persistent infection is considered the main one. Novel therapeutic strategies are based on targeting specific molecules such as epidermal growth factor receptor (EGFR) by applying anti-EGFR monoclonal antibodies (mABs) that block their natural ligands interrupting also aberrant signal transduction to nucleus. Anti-EGFR therapies combined or not with radiotherapy seem to be a very promising tool in handling the corresponding patients with NPC that demonstrate specific genetic signatures. In the current article, we focused on presenting EGFR expression in NPC combined with novel anti-EGFR agents.
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