Intron distribution and emerging role of alternative splicing in fungi

内含子 RNA剪接 计算生物学 生物 分布(数学) 进化生物学 遗传学 基因 数学 核糖核酸 数学分析
作者
Suraya Muzafar,Ravi Datta Sharma,Neeraj Chauhan,Rajendra Prasad
出处
期刊:Fems Microbiology Letters [Oxford University Press]
卷期号:368 (19) 被引量:27
标识
DOI:10.1093/femsle/fnab135
摘要

ABSTRACT Spliceosomal introns are noncoding sequences that are spliced from pre-mRNA. They are ubiquitous in eukaryotic genomes, although the average number of introns per gene varies considerably between different eukaryotic species. Fungi are diverse in terms of intron numbers ranging from 4% to 99% genes with introns. Alternative splicing is one of the most common modes of posttranscriptional regulation in eukaryotes, giving rise to multiple transcripts from a single pre-mRNA and is widespread in metazoans and drives extensive proteome diversity. Earlier, alternative splicing was considered to be rare in fungi, but recently, increasing numbers of studies have revealed that alternative splicing is also widespread in fungi and has been implicated in the regulation of fungal growth and development, protein localization and the improvement of survivability, likely underlying their unique capacity to adapt to changing environmental conditions. However, the role of alternative splicing in pathogenicity and development of drug resistance is only recently gaining attention. In this review, we describe the intronic landscape in fungi. We also present in detail the newly discovered functions of alternative splicing in various cellular processes and outline areas particularly in pathogenesis and clinical drug resistance for future studies that could lead to the development of much needed new therapeutics.

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