肠道菌群
毛螺菌科
化学
果聚糖
食品科学
双歧杆菌
人口
肥胖
生物化学
蔷薇花
益生元
生物
内分泌学
内科学
发酵
厚壁菌
医学
果糖
乳酸菌
16S核糖体RNA
环境卫生
基因
作者
Chengnan Zhang,Abdullah Abdulaziz Abbod Abdo,Benariba Kaddour,Qiuhua Wu,Xin Liang,Guangsen Fan,Guangsen Fan,Teng Chen
标识
DOI:10.1016/j.jff.2019.103622
摘要
In recent years, xylan-oligosaccharides (XOS) have attracted much interest as an alternative sweetener for formulating an anti-obesity diet. The present study combining the plasma metabolic profile and gut microbiota analyses investigated the anti-obesity activity of XOS and the possible mechanism in mice. Our results showed that the dietary supplementations with 5% and 10% XOS could significantly slow down the body weight gaining and improve glucose intolerance. Lipidomic analyses revealed an alternation in 31 metabolic molecules, in particular the ceramide and diacylglycerol species, in the plasma, which were associated with the XOS supplement. Furthermore, gut microbiota analysis showed that XOS changed the composition of gut microbiota, leading to an increase in the relative population of genus Bifidobacterium, Lachnospiraceae_NK4A136_group and Roseburia. In conclusion, the XOS supplementation could reduce the progression of obesity, improve glucose intolerance, and change the plasma lipid profile and gut microbiota composition.
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