Nanoadsorbents Based on NIPAM and Citric Acid: Removal Efficacy of Heavy Metal Ions in Different Media

Heavy metal ions in aqueous solutions are harmful to human health, but exploring and exploiting nanoadsorbents with a high adsorption capacity and low cost should be an effective method for overcoming this problem. In this study, a novel nanoadsorbent termed poly(N-isopropylacrylamide-co-citric acid) (PNCA) was designed and synthesized via free-radical polymerization. PNCA exhibits good solubility in aqueous solutions and can self-assemble into spherical nanoaggregates with a mean hydrodynamic diameter of approximately 723.1 nm. After freeze-drying, the solid powder of PNCA exhibited a loose porous structure. When PNCA is dissolved in water, the resulting copolymer solution exhibits high removal rates for Cu2+ and Pb2+ of over 80%; meanwhile, over 97% of the PNCA is precipitated with metal ions. The adsorption process of PNCA chelated with Cu2+ ions fit the Freundlich model. The adsorption capacity is independent of the media pH, but could be affected by the temperature. Except for herbal medicines with alkaloids as active ingredients, PNCA also presents good adsorption capacity for Cu2+ in herbal medicine decoctions, with a removal rate of over 80%. The cell cytotoxicity in vitro and system toxicity in vivo demonstrate the desirable biosafety of PNCA. These results suggest that PNCA with good biosafety can be utilized as a nanoadsorbent to remove the metal ions, especially Cu2+, in different media.