一氧化氮
环磷酸鸟苷
环gmp
医学
鸟苷酸环化酶
效应器
可溶性鸟苷酰环化酶
第二信使系统
鸟苷
鸟苷酸
细胞内
药理学
内科学
内分泌学
细胞生物学
免疫学
生物化学
化学
受体
生物
核苷酸
基因
摘要
Pivotal advances in basic scientific investigation have led to innovative drugs that have reduced the burden of cardiovascular disease in humans. There is no better example than the Nobel Prize–winning work of Furchgott, Ignarro, and Murad, who discovered that nitric oxide is an endothelial relaxing factor that mediates its favorable cardiovascular actions with the effector molecule 3′,5′-cyclic guanosine monophosphate (GMP).1 Subsequent studies established that the key target of nitric oxide is activation of soluble guanylyl (sometimes called “guanylate”) cyclase, which generates cyclic GMP. Indeed, cyclic GMP has emerged as a key intracellular second messenger that mediates protective cardiovascular, renal, neurohormonal, . . .
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