盐皮质激素受体
医学
内科学
心功能曲线
射血分数
内分泌学
心脏纤维化
氧化应激
血压
盐皮质激素
纤维化
炎症
心肌梗塞
冲程容积
相伴的
心输出量
心脏病学
受体
心力衰竭
作者
Asadur Rahman,Tatsuya Sawano,Anupoma Sen,Akram Hossain,Nourin Jahan,Hideki Kobara,Tsutomu Masaki,Shinji Kosaka,Kento Kitada,Daisuke Nakano,Takeshi Imamura,Hiroyuki Ohsaki,Akira Nishiyama
摘要
We investigated the effects of esaxerenone, a novel, nonsteroidal, and selective mineralocorticoid receptor blocker, on cardiac function in Dahl salt-sensitive (DSS) rats. We provided 6-week-old DSS rats a high-salt diet (HSD, 8% NaCl). Following six weeks of HSD feeding (establishment of cardiac hypertrophy), we divided the animals into the following two groups: HSD or HSD + esaxerenone (0.001%, w/w). In survival study, all HSD-fed animals died by 24 weeks of age, whereas the esaxerenone-treated HSD-fed animals showed significantly improved survival. We used the same protocol with a separate set of animals to evaluate the cardiac function by echocardiography after four weeks of treatment. The results showed that HSD-fed animals developed cardiac dysfunction as evidenced by reduced stroke volume, ejection fraction, and cardiac output. Importantly, esaxerenone treatment decreased the worsening of cardiac dysfunction concomitant with a significantly reduced level of systolic blood pressure. In addition, treatment with esaxerenone in HSD-fed DSS rats caused a reduced level of cardiac remodeling as well as fibrosis. Furthermore, inflammation and oxidative stress were significantly reduced. These data indicate that esaxerenone has the potential to mitigate cardiac dysfunction in salt-induced myocardial injury in rats.
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