Effect of calcium sodium phosphosilicate–containing compared to nanohydroxyapatite-containing toothpastes on dentinal tubule occlusion: A randomized clinical in situ study

Aim: Treatment of dentin hypersensitivity is a challenging procedure; the evolution of many materials dictates the necessity of comparing them to choose the one with rapid and sustained effect. The aim of this study was to compare between calcium sodium phosphosilicate (Ca-Na-P) containing toothpaste and nanohydroxyapatite (n-HA) containing toothpaste in treatment of dentin hypersensitivity by occlusion of dentinal tubules using a novel intraoral appliance in situ. Materials and Methods: A total number of 42 patients were assigned randomly to receive intraoral appliances holding sterilized dentin specimens on the upper first molars to one of the two groups:; either calcium sodium phosphosilicate-containing or n-HAnanohydroxyapatite-containing toothpastes. A total of 63 lower premolars were used to obtain dentin specimens. Dentin specimens were examined under scanning electron microscope. Dentinal tubules were counted visually to determine the percentages of their occlusion:; pretreatment and after 24 hours, six weeks, and eight weeks of toothpastes’ application. Data wereas collected and analyzed using Kruskall-Wallis test and Mann-Whitney test. Results: There was a significant increase in dentinal occlusion scores for both materials at a P value of ≤0.001. n-HA showed significant higher scores compared to Ca-Na-P at all follow-up periods (P ≤ 0.001). Conclusion: Biomimetic zinc n-HAcontaining toothpaste proved immediate dentinal tubule occlusion; moreover, both toothpastes provided long-term tubules occlusion.