浣熊
多巴胺
表号:SCH-23390
多巴胺转运体
多巴胺受体D2
多巴胺受体D1
化学
伏隔核
多巴胺拮抗剂
多巴胺受体
内科学
纹状体
内分泌学
生物
医学
多巴胺能
氟哌啶醇
作者
Wayne A. Cass,Greg A. Gerhardt
标识
DOI:10.1016/0304-3940(94)90096-5
摘要
In vivo electrochemistry was used to determine the effects of locally applied raclopride (a D2 receptor antagonist) and SCH-23390 (a D1 receptor antagonist) on the clearance of locally applied dopamine in the striatum, nucleus accumbens, and medial prefrontal cortex of rats. Chronoamperometric recordings were continuously made at 5 Hz using Nafion-coated, single carbon fiber electrodes. When a calibrated amount of dopamine was pressure ejected at 5-min intervals from a micropipette adjacent (280–310 μm) to the electrode, transient and reproducible dopamine signals were detected in all three regions. Local application of raclopride from a second micropipette, prior to pressure ejection of dopamine, increased the amplitude and time course of the dopamine signals, indicating significant inhibition of the dopamine transporter. In contrast, local application of SCH-23390 or saline had no effect on the dopamine signals. These data indicate that D2, but not D1, dopamine receptors can modulate the activity of the dopamine transporter.
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