狂犬病病毒
乙酰胆碱受体
溶血酶
乙酰胆碱
肌发生
病毒
狂犬病
受体
弹状病毒科
生物
病毒学
细胞生物学
心肌细胞
内分泌学
生物化学
作者
Thomas L. Lentz,Thomas G. Burrage,Abigail L. Smith,Joan Crick,Gregory H. Tignor
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1982-01-08
卷期号:215 (4529): 182-184
被引量:425
标识
DOI:10.1126/science.7053569
摘要
Rabies virus was found on mouse diaphragms and on cultured chick myotubes in a distribution coinciding with that of the acetylcholine receptor. Treatment of the myotubes with alpha-bungarotoxin and d-tubocurarine before the addition of the virus reduced the number of myotubes that became infected with rabies virus. These findings together suggest that acetylcholine receptors may serve as receptors for rabies virus. The binding of virus to acetylcholine receptors, which are present in high density at the neuromuscular junction, would provide a mechanism whereby the virus could be locally concentrated at sites in proximity to peripheral nerves facilitating subsequent uptake and transfer to the central nervous system.
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