子宫内膜异位症
子宫内膜
巨噬细胞
免疫染色
川地68
川地163
人口
医学
免疫组织化学
男科
内科学
病理
生物
体外
生物化学
环境卫生
作者
Akie Takebayashi,Fuminori Kimura,Yohei Kishi,Mitsuaki Ishida,Akimasa Takahashi,Akiyoshi Yamanaka,Di Wu,Luyi Zheng,Kentaro Takahashi,Hiroshi Suginami,Takashi Murakami
摘要
Problem Endometriosis is recognized as a chronic inflammatory disease and is related to immune response. There have been reports that revealed the different distribution of macrophage within the eutopic endometrium of women with endometriosis. Macrophages are functionally polarized into M1 and M2 cell lineages. We studied a difference in the subpopulations of M1 and M2 macrophages within the eutopic endometrium in patients with or without endometriosis to investigate how the eutopic endometrium is stimulated immunologically. Method of study Thirty‐six patients with endometriosis (endometriosis group) and 37 without endometriosis (non‐endometriosis group) were analyzed. Paraffin‐embedded endometrial specimens were used for the study. Consecutive sections were used for immunostaining of CD 68 (pan‐macrophage marker) and CD 163 (M2 macrophage marker). Cells positive for each marker were quantified, and the ratio of M2 macrophages in pan‐macrophages was calculated. Result The endometriosis group had a significantly higher number of pan‐macrophages than the control group in all phases ( P < 0.05). The ratios of M2 macrophages in pan‐macrophages were significantly lower in all phases in the endometriosis group ( P < 0.05). Conclusion The macrophage population slants toward M1 in the endometrium of endometriosis patients. The endometrium appeared to be stimulated by some organelles and/or substances that induce M1 in endometriosis patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI