Synthesis Of β-D-Mannose Containing Oligosaccharides*

The chemical synthesis of β-D-mannopyranosides is reviewed with emphasis placed on naturally occurring structures. The insoluble promoter strategy and oxidation-reduction method are discussed as the two most often used procedures to synthesize β-D-mannosides. In addition, the use of 2-oxo glycosyl halides and inter and intramolecular nucleophiles are examined. Finally, intramolecular aglycon delivery is discussed as an alternative method to make β-D-mannopyranosides with complete stereocontrol.