慢性淋巴细胞白血病
IGHV@
病因学
非洲人后裔
免疫学
入射(几何)
白血病
医学
生物
病理
谱系学
历史
光学
物理
作者
Shenmiao Yang,Jianyong Li,Robert Peter Gale,Xiao‐Jun Huang
出处
期刊:Blood Reviews
[Elsevier]
日期:2015-05-01
卷期号:29 (3): 205-213
被引量:57
标识
DOI:10.1016/j.blre.2014.12.001
摘要
Chronic lymphocytic leukemia/small lymphocytic lymphoma is common in persons of predominately European descent but rare in Asians. Why is unknown but is likely genetically-determined. Environmental factors may also operate but are likely to be less important. When CLL occurs in Asians it has different features than CLL in persons of predominately European descent. The reason(s) for this is also not understood. We reviewed data on CLL in Asians (mostly Han Chinese but also other ethnic groups) and compared these data with those from persons of predominately European descent with CLL. CLL incidence was about 5–10-fold less in Asians. Asians with CLL are younger, have atypical morphologic and immunologic features, an increased proportion of IGHV mutations and rearrangements and briefer freedom-from-progression than persons of predominately European descent with CLL. These observations provide clues to the etiology and biology of CLL. But the mystery continues; more research is needed.
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