Negishi偶联反应
化学
试剂
苯
偶联反应
联轴节(管道)
催化循环
药物化学
有机化学
催化作用
冶金
材料科学
作者
Christopher J. Adams,Robin B. Bedford,Emma Carter,Nicholas J. Gower,Mairi F. Haddow,Jeremy N. Harvey,Michael Huwe,Marcela Cartes,Stephen M. Mansell,Carla Mendoza,D. M. Murphy,Emily C. Neeve,Joshua Nunn
摘要
Herein we demonstrate both the importance of Fe(I) in Negishi cross-coupling reactions with arylzinc reagents and the isolation of catalytically competent Fe(I) intermediates. These complexes, [FeX(dpbz)2] [X = 4-tolyl (7), Cl (8a), Br (8b); dpbz = 1,2-bis(diphenylphosphino)benzene], were characterized by crystallography and tested for activity in representative reactions. The complexes are low-spin with no significant spin density on the ligands. While complex 8b shows performance consistent with an on-cycle intermediate, it seems that 7 is an off-cycle species.
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